药物输送
脚手架
组织工程
纳米技术
生物相容性材料
计算机科学
生化工程
生物医学工程
医学
材料科学
工程类
作者
Carmen J. Gil,Lan Li,Boeun Hwang,Melissa Cadena,Andrea S. Theus,Tyler A. Finamore,Holly Bauser‐Heaton,Morteza Mahmoudi,Ryan K. Roeder,Vahid Serpooshan
标识
DOI:10.1016/j.jconrel.2022.04.044
摘要
Tissue engineering is a rapidly evolving, multidisciplinary field that aims at generating or regenerating 3D functional tissues for in vitro disease modeling and drug screening applications or for in vivo therapies. A variety of advanced biological and engineering methods are increasingly being used to further enhance and customize the functionality of tissue engineered scaffolds. To this end, tunable drug delivery and release mechanisms are incorporated into tissue engineering modalities to promote different therapeutic processes, thus, addressing challenges faced in the clinical applications. In this review, we elaborate the mechanisms and recent developments in different drug delivery vehicles, including the quantum dots, nano/micro particles, and molecular agents. Different loading strategies to incorporate the therapeutic reagents into the scaffolding structures are explored. Further, we discuss the main mechanisms to tune and monitor/quantify the release kinetics of embedded drugs from engineered scaffolds. We also survey the current trend of drug delivery using stimuli driven biopolymer scaffolds to enable precise spatiotemporal control of the release behavior. Recent advancements, challenges facing current scaffold-based drug delivery approaches, and areas of future research are discussed.
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