化学
化学选择性
电化学
异构化
组合化学
表面改性
分子
异硫氰酸盐
功能群
有机化学
催化作用
电极
物理化学
聚合物
作者
Shanxue Zhang,Yufeng Li,Tao Wang,Ming Li,Li‐Rong Wen,Wei‐Si Guo
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-02-24
卷期号:24 (8): 1742-1746
被引量:22
标识
DOI:10.1021/acs.orglett.2c00415
摘要
Selective C(sp3)-H isothiocyanation represents a significant strategy for the synthesis of isothiocyanate derivatives. We report herein an electrochemical benzylic isothiocyanation in a highly chemo- and site-selective manner under external oxidant-free conditions. The high chemoselectivity is attributed to the facile in situ isomerization of benzylic thiocyanates to isothiocyanates. Notably, the method exhibits high functional group compatibility and is suitable for late-stage functionalization of bioactive molecules.
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