内科学
内分泌学
丙种皮质醇
下丘脑
瘦素
神经肽Y受体
排卵
促性腺激素释放激素
生物
小鼠苗条素受体
神经肽
医学
激素
受体
促黄体激素
肥胖
作者
Xiaolin Chen,Zhuoni Xiao,Yuli Cai,Lili Huang,Chen Chen
标识
DOI:10.1016/j.tem.2021.12.004
摘要
Ovulatory disorders are the most common clinical feature exhibited among obese women. Initiation of ovulation physiologically requires a surge of gonadotropin-releasing hormone (GnRH) released from GnRH neurons located in the hypothalamus. These GnRH neurons receive metabolic signals from circulation and vicinal neurons to regulate GnRH release. Leptin acts indirectly on GnRH via adjacent leptin receptor (LEPR)-expressing neurons such as proopiomelanocortin (POMC), neuropeptide Y (NPY)/agouti-related peptide (AgRP), and neuronal nitric oxide (NO) synthase (nNOS) neurons to affect GnRH neuronal activities. Additionally, hypothalamic inflammation also affects ovulation independent of obesity. Therefore, this review focuses on hypothalamic mechanisms that underlie the disturbance of hypothalamic-pituitary-ovarian (HPO) axis during obesity with an attempt to promote future studies and/or novel therapeutic strategies for ovulatory disorders in obesity.
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