渲染(计算机图形)
化学
概括性
生化工程
组合化学
纳米技术
计算机科学
工程类
材料科学
心理学
人工智能
心理治疗师
作者
Marre Porré,Gianmarco Pisanò,Fady Nahra,Catherine S. J. Cazin
出处
期刊:Molecules
[Multidisciplinary Digital Publishing Institute]
日期:2022-06-02
卷期号:27 (11): 3583-3583
被引量:19
标识
DOI:10.3390/molecules27113583
摘要
α-Haloketones play an essential role in the synthesis of complex N-, S-, O-heterocycles; of which some exhibit a remarkable biological activity. Research further illustrated that α-bromo-, α-chloro-, and α-iodoketones are key precursors for blockbuster pharmacological compounds. Over the past twenty years, substantial advances have been made in the synthesis of these industrially relevant building blocks. Efforts have focused on rendering the synthetic protocols greener, more effective and versatile. In this survey, we summarised and thoroughly evaluated the progress of the field, established in the past two decades, in terms of generality, efficacy and sustainability.
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