微流控
肿瘤微环境
细胞外基质
转移
癌细胞
癌症
肿瘤进展
生物
细胞迁移
肿瘤细胞
细胞
纳米技术
细胞生物学
癌症研究
材料科学
遗传学
作者
Pranav Mehta,Zaid Rahman,Peter ten Dijke,Pouyan E. Boukany
标识
DOI:10.1016/j.trecan.2022.03.006
摘要
An early step of metastasis requires a complex and coordinated migration of invasive tumor cells into the surrounding tumor microenvironment (TME), which contains extracellular matrix (ECM). It is being appreciated that 3D matrix-based microfluidic models have an advantage over conventional in vitro and animal models to study tumor progression events. Recent microfluidic models have enabled recapitulation of key mechanobiological features present within the TME to investigate collective cancer cell migration and invasion. Microfluidics also allows for functional interrogation and therapeutic manipulation of specific steps to study the dynamic aspects of tumor progression. In this review, we focus on recent developments in cancer cell migration and how microfluidic strategies have evolved to address the physiological complexities of the TME to visualize migration modes adapted by various tumor cells.
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