表观遗传学
小RNA
结直肠癌
长非编码RNA
癌症
癌症研究
生物
竞争性内源性RNA
生物信息学
核糖核酸
计算生物学
医学
基因
遗传学
作者
Shirin Azizidoost,Farhoodeh Ghaedrahmati,Omid Anbiyaee,Riyadh Ahmad Ali,Maryam Cheraghzadeh,Maryam Farzaneh
标识
DOI:10.1186/s12935-022-02627-6
摘要
Colorectal cancer (CRC) is the third cause of cancer death in the world that arises from the glandular and epithelial cells of the large intestine, during a series of genetic or epigenetic alternations. Recently, long non-coding RNAs (lncRNAs) has opened a separate window of research in molecular and translational medicine. Emerging evidence has supported that lncRNAs can regulate cell cycle of CRC cells. LncRNA NEAT1 has been verified to participate in colon cancer development and progression. NEAT1 as a competing endogenous RNA could suppress the expression of miRNAs, and then regulate molecules downstream of these miRNAs. In this review, we summarized emerging roles of NEAT1 in CRC cells.
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