药物输送
纳米技术
药品
生化工程
计算机科学
材料科学
药理学
医学
工程类
作者
Ravinder Verma,Vineet Mittal,Parijat Pandey,Saurabh Bhatia,Meenakshi Bhatia,Christina Karavasili,Tapan Behl,Ahmed Al‐Harrasi,Priti Tagde,Manish Kumar,Deepak Kaushik
出处
期刊:Current Drug Delivery
[Bentham Science]
日期:2023-11-01
卷期号:20 (9): 1241-1261
被引量:6
标识
DOI:10.2174/1567201819666220519125003
摘要
Nanotechnology has attracted researchers around the globe owing to the small size and targeting properties of the drug delivery vectors. The interest in self-nanoemulsifying drug delivery systems (SNEDDS) has shown an exponential increase from the formulator's point of view. SNEDDS have shown wide applicability in terms of controlled and targeted delivery of various types of drugs. They chemically consist of oil, surfactants and co-surfactants that decrease the emulsion particle size to the range of <100 nm. However, stability issues such as drug precipitation during storage, incompatibility of ingredients in shell, decrease their application for the long run and these issues have been highlighted in this paper. The current review throws limelight on the biological aspects and process parameters. In addition, the process of absorption from GI is also discussed in detail. SNEDDS have been utilized as a treatment option for various diseases like cancer, diabetes, and ocular and pulmonary diseases. Along with this, the authors highlight the advances involving in vivo and in vitro lipolysis studies on SNEDDS, also highlighting recent innovations in this field, such as novel combinations of drug-free solid SNEDDS + solid dispersions, lipid-modified chitosan containing mucoadhesive SNEDDS, pHsensitive SNEDDS and several others.
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