抗菌剂
抗菌肽
广谱
作用机理
医学
抗生素耐药性
计算生物学
机制(生物学)
化学
抗生素
生物
微生物学
组合化学
生物化学
体外
认识论
哲学
作者
Qiyu Zhang,Zhibin Ye,Yueming Meng,Xiangyu Hong,Gang Shao,Junjie Ma,Xurui Cheng,Jun Li,Jian Kang,Caiyun Fu
标识
DOI:10.1186/s40779-021-00343-2
摘要
The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin, structural characteristics, mechanisms of action, biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics.
科研通智能强力驱动
Strongly Powered by AbleSci AI