活性氧
材料科学
光热治疗
过氧化物酶
催化作用
化学
生物物理学
交货地点
合金
体内
光化学
纳米技术
生物化学
酶
有机化学
生物
生物技术
农学
作者
Deblin Jana,Dongdong Wang,Anivind Kaur Bindra,Yi Guo,Jiawei Liu,Yanli Zhao
出处
期刊:ACS Nano
[American Chemical Society]
日期:2021-04-12
卷期号:15 (4): 7774-7782
被引量:116
标识
DOI:10.1021/acsnano.1c01830
摘要
The therapeutic effect of chemodynamic therapy (CDT) is significantly restricted by the stern reaction conditions and slow reaction rate of the Fenton reaction (pH 3–4). Herein, we report an ultrasmall trimetallic (Pd, Cu, and Fe) alloy nanozyme (PCF-a NEs) possessing dynamic active-site synergism, thus exhibiting a cascade glutathione peroxidase and peroxidase (POD) mimicking activities in circumneutral pH. PCF-a NEs exhibit photothermally augmented POD property and high photothermal conversion efficiency (62%) for synergistic tumor cell apoptosis. In addition, ultrasound can also enhance the mass transfer at active catalytic sites of PCF-a NEs, in turn accelerating Fenton-like reaction for tumor-specific CDT. This work provides a strategy for engineering alloy nanozymes in a bioinspired way for the amplification of intratumor reactive oxygen species in response to external stimuli, demonstrating enhanced efficiency for the inhibition of tumor growth in vitro and in vivo.
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