[Preparation and applications of the polymeric micelle/hydrogel nanocomposites as biomaterials].

Polymeric hydrogels have been widely researched as drug delivery systems, wound dressings and tissue engineering scaffolds due to their unique properties such as good biocompatibility, shaping ability and similar properties to extracellular matrix. However, further development of conventional hydrogels for biomedical applications is still limited by their poor mechanical properties and self-healing properties. Currently, nanocomposite hydrogels with excellent properties and customized functions can be obtained by introducing nanoparticles into their network, and different types of nanoparticles, including carbon-based, polymer-based, inorganic-based and metal-based nanoparticle, are commonly used. Nanocomposite hydrogels incorporated with polymeric micelles can not only enhance the mechanical properties, self-healing properties and chemical properties of hydrogels, but also improve the in vivo stability of micelles. Therefore, micelle-hydrogel nanocomposites have been recently considered as promising biomaterials. In this paper, the structure, properties and methods for preparation of the micelle-hydrogel nanocomposite systems are introduced, and their applications in drug delivery, wound treatment and tissue engineering are reviewed, aiming to provide reference for further development and application of the nanocomposites.聚合物水凝胶由于具有良好的生物相容性、塑形能力以及类似细胞外基质的性能特点，作为药物缓释材料、伤口敷料、组织工程支架等在生物医学领域得到了广泛的应用。但目前水凝胶的进一步发展仍然受限于其较差的力学性能和自愈性能。在水凝胶网络中引入不同类型的纳米粒子，如碳基、聚合物基、无机基和金属基纳米颗粒，是获得具有优异性能和定制功能的纳米复合水凝胶的常用方法。在水凝胶网络中引入聚合物纳米胶束获得的聚合物胶束-水凝胶复合体，不仅能增强水凝胶的机械性能、自愈性能和化学性能，还可以改善胶束的体内稳定性，作为生物材料具有良好的应用前景。本文对聚合物胶束-水凝胶复合体系的结构、性质进行了简要介绍，并重点综述了该体系的制备方法以及作为药物载体、伤口敷料、组织工程的应用研究进展，为该复合体系进一步的开发应用提供参考。.