免疫系统
生物
免疫学
获得性免疫系统
免疫
先天性淋巴细胞
先天免疫系统
细胞因子
神经科学
细胞生物学
作者
Sharon S. Evans,Elizabeth A. Repasky,Daniel Fisher
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2015-05-15
卷期号:15 (6): 335-349
被引量:764
摘要
Fever is a cardinal response to infection that has been conserved in warm-blooded and cold-blooded vertebrates for more than 600 million years of evolution. The fever response is executed by integrated physiological and neuronal circuitry and confers a survival benefit during infection. In this Review, we discuss our current understanding of how the inflammatory cues delivered by the thermal element of fever stimulate innate and adaptive immune responses. We further highlight the unexpected multiplicity of roles of the pyrogenic cytokine interleukin-6 (IL-6), both during fever induction and during the mobilization of lymphocytes to the lymphoid organs that are the staging ground for immune defence. We also discuss the emerging evidence suggesting that the adrenergic signalling pathways associated with thermogenesis shape immune cell function.
科研通智能强力驱动
Strongly Powered by AbleSci AI