How to define a Minimal Clinically Individual State (MCIS) with pain VAS in daily practice for patients suffering from musculoskeletal disorders.

医学 可视模拟标度 物理疗法 慢性疼痛 疾病 临床试验 内科学
作者
Géraldine Falgarone,Djamila Zerkak,Christoph Bauer,Claudia-Martina Messow,Maxime Dougados
出处
期刊:PubMed 卷期号:23 (2): 235-8 被引量:4
链接
标识
摘要

Pain is frequently the primary variable in symptomatic clinical trials for the evaluation of rheumatological disorders. The protocol of such trials mention a minimum level of pain as an entry criterion [e.g. a level above the Patient Acceptable Symptoms State (PASS)] and the changes in pain as the primary variable. Usually, the results are expressed at a group level as the mean changes in pain. However, the presentation at an individual level and, in particular, the percentage of patients with a Low Disease Activity State at the end of the study seems more clinically relevant. Pain is usually evaluated using a continuous variable such as a 0-100 visual analogue scale. The cut-offs permitting one to define both the entry criterion and the LDAS are not well established. The objective of this study was to evaluate such cut-offs using a patient-derived perspective.cross-sectional study.consecutive out patients suffering from chronic rheumatic diseases familiar with the use of a VAS to evaluate their level of pain.two questions were asked the patients at the end of the visit: "Based on the experience you have because of your chronic rheumatic disorder, could you please specify the level of pain below which you consider your disease as inactive ? Moreover, could you please also specify the level of pain above which you consider taking a pain killer?" Before answering the second question, it was explained to the patient that their answer to the second question could be similar to their response to the first one. For the two questions, the cumulative percentage of patients (disease inactive and pain killer intake) were calculated for each level of pain.The underlying disease of the 137 evaluated patients (mean age: 57+/-16 and female sex: 76%) was rheumatoid arthritis (n = 59), ankylosing spondylitis (n = 19), SLE (n = 2), back pain (n = 20), or peripheral osteoarthritis (n = 37). The mean disease duration was 12+/-10 years. At the time of the study, the current level of pain evaluated on a 0-100 VAS was 33+/-22. The LDAS was 49, 36 and 25 for our patient population at the 25th, 50th and 75th percentiles, respectively. The pain killer intake level was 32, 48, 64 at the 25th, 50th, 75th percentile respectively.This study suggests that LDAS and PASS may be distinct concepts. The methodological approach adopted here could be of interest for specifying the minimum level of symptoms at entry in a symptomatic trial (PASS) and also to present results in terms of the percentage of patients in good condition (LDAS) at the end of a trial.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
5秒前
美女的事你少管完成签到 ,获得积分0
6秒前
劉劉发布了新的文献求助10
8秒前
临时演员完成签到,获得积分10
9秒前
震南发布了新的文献求助10
11秒前
12秒前
野田洋次郎完成签到,获得积分10
13秒前
14秒前
贪玩的丹蝶完成签到,获得积分20
14秒前
14秒前
风雪雅尘完成签到,获得积分10
15秒前
小绵羊发布了新的文献求助10
17秒前
shuang0116发布了新的文献求助10
18秒前
zhangsan完成签到,获得积分10
18秒前
我是老大应助xiaohongmao采纳,获得10
19秒前
劉劉完成签到 ,获得积分10
20秒前
planto完成签到,获得积分10
20秒前
东方三问完成签到,获得积分10
21秒前
常存喜乐完成签到 ,获得积分10
22秒前
向日葵完成签到,获得积分10
23秒前
每天都在找完成签到,获得积分10
25秒前
现实完成签到,获得积分20
25秒前
planto发布了新的文献求助30
26秒前
loga80完成签到,获得积分10
27秒前
29秒前
khh完成签到 ,获得积分10
29秒前
开拖拉机的医学僧完成签到 ,获得积分10
30秒前
韩较瘦完成签到,获得积分10
31秒前
现实发布了新的文献求助10
34秒前
511完成签到 ,获得积分10
37秒前
哈哈里完成签到 ,获得积分20
37秒前
shuang0116完成签到 ,获得积分0
38秒前
H_sH完成签到 ,获得积分10
43秒前
深情的起眸完成签到 ,获得积分10
44秒前
妩媚的以寒完成签到 ,获得积分20
44秒前
jeronimo完成签到,获得积分10
46秒前
你看起来很好吃完成签到,获得积分10
47秒前
bkagyin应助明理的青寒采纳,获得10
51秒前
58秒前
浩浩完成签到 ,获得积分10
1分钟前
高分求助中
Un calendrier babylonien des travaux, des signes et des mois: Séries iqqur îpuš 1036
Sustainable Land Management: Strategies to Cope with the Marginalisation of Agriculture 1000
Corrosion and Oxygen Control 600
Python Programming for Linguistics and Digital Humanities: Applications for Text-Focused Fields 500
Heterocyclic Stilbene and Bibenzyl Derivatives in Liverworts: Distribution, Structures, Total Synthesis and Biological Activity 500
重庆市新能源汽车产业大数据招商指南(两链两图两池两库两平台两清单两报告) 400
Division and square root. Digit-recurrence algorithms and implementations 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2546297
求助须知:如何正确求助?哪些是违规求助? 2175702
关于积分的说明 5600550
捐赠科研通 1896461
什么是DOI,文献DOI怎么找? 946308
版权声明 565379
科研通“疑难数据库(出版商)”最低求助积分说明 503557