免疫学
肿瘤微环境
医学
癌症研究
癌症
免疫疗法
嵌合抗原受体
淋巴因子激活杀伤细胞
自然杀伤细胞
生物
细胞毒性T细胞
免疫系统
内科学
作者
Khalil Choucair,Joseph R Duff,Christine S Cassidy,Mary T Albrethsen,Jesse D Kelso,Amanda Lenhard,Hannah Staats,Rayna Patel,F. Charles Brunicardi,Lance D. Dworkin,John Nemunaitis
出处
期刊:Future Oncology
[Future Medicine]
日期:2019-08-14
卷期号:15 (26): 3053-3069
被引量:27
标识
DOI:10.2217/fon-2019-0116
摘要
Natural killer (NK) cells lead immune surveillance against cancer and early elimination of small tumors. Owing to their ability to engage tumor targets without the need of specific antigen, the therapeutic potential of NK cells has been extensively explored in hematological malignancies. In solid tumors, however, their role in the clinical arena remains poorly exploited despite a broad accumulation of preclinical data. In this article, we review our current knowledge of NK cells’ biology, and highlight the challenges facing NK cell antitumor strategies in solid tumors. We further summarize the abundant preclinical attempts at overcoming these challenges, present past and ongoing clinical trial data and finally discuss the potential impact of novel insights on the development of NK cell-based therapies.
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