精子
细菌
生物
精子发生
精液
男性不育
DNA断裂
男科
生育率
不育
细胞凋亡
程序性细胞死亡
内分泌学
遗传学
医学
人口
环境卫生
怀孕
作者
Hajar Oghbaei,Yeganeh Rastgar Rezaei,Saba Nikanfar,Reza Zarezadeh,Mohammadreza Sadegi,Zeinab Latifi,Mohammad Nouri,Amir Fattahi,Yasin Ahmadi,Nathalie Bleisinger
出处
期刊:Life Sciences
[Elsevier]
日期:2020-09-01
卷期号:256: 117891-117891
被引量:23
标识
DOI:10.1016/j.lfs.2020.117891
摘要
Bacterial infection can negatively affect different parts of the male genital tract and subsequently cause impaired spermatogenesis and male fertility. However, most of the previous studies have focused on the infected organs of the male genital tract and there are not many studies that investigated the direct effect of bacteria on sperm and their mechanism of action. Interestingly, bacteria can induce different damages on sperm cells such as DNA fragmentation, cell membrane peroxidation, and acrosome impairment. Such negative effects can be mediated by bacteria-secreted toxins and metabolites or by direct attachment of bacteria on the sperm cells and subsequent activation of signaling pathways related to oxidative stress, apoptosis, and inflammation. These bacteria-induced changes can impair semen parameters and subsequently cause infertility. Given the significant destructive effect of some bacteria on sperm function and male fertility, in this study, we reviewed the impact of male urogenital bacteria on spermatogenesis and sperm functions as well as the underlying mechanisms by which the bacteria can damage sperm.
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