医学
荟萃分析
肺癌
置信区间
肺癌筛查
相对风险
科克伦图书馆
随机对照试验
人口
内科学
梅德林
癌症
环境卫生
政治学
法学
作者
Alexandre Sadate,Bob-valery Occean,Jean-Paul Bérégi,Aymeric Hamard,Takieddine Addala,Hélène de Forges,Pascale Fabbro-Pèray,Julien Frandon
标识
DOI:10.1016/j.ejca.2020.04.035
摘要
Abstract
Introduction
Lung cancer (LC) has the highest cancer mortality worldwide with poor prognosis. Screening with low-dose computed tomography (LDCT) in populations highly exposed to tobacco has been proposed to improve LC prognosis. Our objective was to perform a systematic review and meta-analysis to evaluate the efficacy of screening by LDCT compared with any other intervention in populations who reported tobacco consumption for more than 15 years on LC and overall mortality. Methods
We searched randomised controlled trials (RCTs) studying screening by LDCT compared with any other intervention in a population who reported an average smoking history greater than 15 pack-years from inception until the 19th February 2018 using Medline and Cochrane Library databases. Publication selection and data extraction were made independently by two double-blind reviewers. Results
Seven RCTs were included in the meta-analysis which corresponds to 84,558 participants. A significant relative reduction of LC-specific mortality of 17% (risk ratio [RR] = 0.83, 95% confidence interval [CI]: 0.76–0.91) and a relative reduction of overall mortality of 4% (RR = 0.96, 95% CI: 0.92–1.00) was observed in the screening group compared with the control group. Conclusion
In populations highly exposed to tobacco, screening by LDCT reduces lung cancer mortality.
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