粒体自噬
吡啶
光动力疗法
背景(考古学)
活性氧
线粒体
烷基
生物物理学
纳米技术
化学
材料科学
生物化学
自噬
生物
有机化学
细胞凋亡
古生物学
作者
Yuyang Zhang,Lianke Wang,Qingpeng Rao,Yingcui Bu,Tianren Xu,Xiaojiao Zhu,Jie Zhang,Yupeng Tian,Hongping Zhou
标识
DOI:10.1016/j.snb.2020.128460
摘要
Targeting mitochondria and dynamically tracking mitophagy are profoundly important in the field of photodynamic therapy (PDT) which relies on the photosensitizers (PSs) under light irradiation. While simultaneously realizing the effective reactive oxygen species (ROS) generation, accurately mitochondrial targeting, and dynamic tracking in a single PS still is a challenging issue. In this context, a series of pyridinium-based cationic fluorogens with aggregation induced emission (AIE) has been developed for this issue. The hydrophobicity of these fluorogens can be finely tuned by modulating the length of the alkyl chains on pyridinium unit. The well-tuned hydrophobicity of TL8C with C8-alkyl chain gives rise to the specifically mitochondrial targeting capability of TL8C based on the appropriate synergistic effect of hydrophobic and electrostatic interaction. Meanwhile, TL8C can produce ROS in high efficiency. The excellent mitochondrial targeting and the effective ROS generation allow TL8C for the specifically mitochondria-targeted PDT as well as the real time monitoring of mitophagy.
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