This study has investigated the relationship of the retinal vasculature and the retinal thickness for Macular Edema (ME) subjects. Ninety sets of Fluorescein Angiograph (FA) and Optical Coherence Tomography (OCT) of 54 participants were analyzed. Multivariate analysis using the binary logistic regression model was used to study the association between vessel parameters and retinal thickness. The results reveal retinal vessel feature i.e. fractal dimension (FD) as the most sensitive parameter to the changes in retinal thickness associated with ME. Thus, indicating a direct relationship between the retinal vasculature and retinal thickness which is caused due to neovascular causing exudates, leakages and hemorrhages, with applications for alternate modality for detection of ME.