精子
微核试验
男科
体细胞
微核
生物
毒性
动物科学
生理学
毒理
内科学
医学
生物化学
基因
作者
Okunola A. Alabi,Mary A. Unuigboje,Daniel O. Olagoke,Yetunde M Adeoluwa
标识
DOI:10.1016/j.mrgentox.2020.503296
摘要
Studies on the toxic effects of cooking with aluminum pots are limited and none of them have explored its impact on the genetic material in germ and somatic cells. Therefore, this study investigated the cytogenotoxic effect of boiled water from new, 3- and 6-year old aluminum pots in germ and somatic cells viz-a-vis mouse sperm morphology test and sperm count; and the bone marrow micronucleus test. The mice were allowed to freely drink the boiled water from the different aluminum pots for 3, 4, and 5 weeks. The heavy metal analysis showed that As, Pb, Cd, and Al were present in the boiled water samples at different concentrations with the 6-year old pot having the highest concentrations of Pb, Cd, and Al. There were duration of exposure and age of pot-dependent significant increase in abnormal sperm cells and a significant decrease total mean sperm count of exposed mice. Similarly, there was a statistically significant increase in micronucleated polychromatic erythrocytes and nuclear abnormalities in the exposed mice that increased dependently upon the age of the cookware. Finally there were significantly increased activities of serum AST and ALT; and the liver concentrations of MDA, SOD and CAT in boiled water exposed mice. The findings of this study revealed that boiled water from aluminum pots is capable of inducing cytotoxic and genotoxic effects, especially as the pot ages.
科研通智能强力驱动
Strongly Powered by AbleSci AI