Clinical analysis of post liver transplantation complications and the risk factors of death by MELD score and CTP classification

Objective To investigate the risk factors of complications and mortality rate after liver transplantation by MELD score and CTP classification. Methods The clinical data of 184 patients undergone liver transplantation were retrospectively analyzed. Patients were divided into three groups respectively according to MELD score and CTP score: group A (MELD≤10), B(MELD>10-20), C(MELD>20)and group a(CTP 5-6), b(CTP 7-9), c(CTP 10-15). Patients were also divided into compli-cations and non-complications group, survival group and death group. Results (1)Clinical indicators of the three groups A, B, C had significant differences in Cr, PT, PT-INR, TBIL, intraoperative average urine volume, intraoperative blood transfusion and blood loss(P<0.05); while the three groups a, b, c showed significant differences in ALB, PT, PT-INR, TBIL, intraoperative average urine volume, intraoperative blood transfusion and blood loss(P<0.05). (2) Hyperbilirubinemia, improper coagulation function and renal function before the operation were the risk factors for complications after liver transplantation. (3) Increased PT, high MELD score, increased intraoperative blood transfusion and decreased intraoperative average urine were the risk factors for death during the perioperative period. Conclusions The higher the MELD score and CTP score, the higher the incidence of complications and mortality rate after liver transplantation. Hyperbilirubinemia, poor coagulation function and renal function are the most important risk factors for complications and mortality rate after liver transplantation. Key words: Liver transplantation; MELD score; CTP classification; Complications; Mortality