Common Genetic Variants Explain the Majority of the Correlation Between Height and Intelligence: The Generation Scotland Study
作者
Generation Scotland,Riccardo E. Marioni,George David Batty,Caroline Hayward,Shona M. Kerr,Archie I Campbell,Lynne J. Hocking,David John Porteous,Peter M. Visscher,Ian J. Deary
Greater height and higher intelligence test scores are predictors of better health outcomes. Here, we used molecular (single-nucleotide polymorphism) data to estimate the genetic correlation between height and general intelligence (g) in 6,815 unrelated subjects (median age 57, IQR 49-63) from the Generation Scotland: Scottish Family Health Study cohort. The phenotypic correlation between height and g was 0.16 (SE 0.01). The genetic correlation between height and g was 0.28 (SE 0.09) with a bivariate heritability estimate of 0.71. Understanding the molecular basis of the correlation between height and intelligence may help explain any shared role in determining health outcomes. This study identified a modest genetic correlation between height and intelligence with the majority of the phenotypic correlation being explained by shared genetic influences.