药物输送
甲壳素
组织工程
原材料
硫酸软骨素
天然聚合物
生化工程
纳米技术
生物技术
壳聚糖
化学
糖胺聚糖
聚合物
材料科学
生物
生物化学
工程类
生物医学工程
有机化学
作者
Tiago H. Silva,Anabela Alves,Branco Ferreira,Joaquím M. Oliveira,Lara L. Reys,Rita Ferreira,Rui A. Sousa,Simone S. Silva,João F. Mano,Rui L. Reis
标识
DOI:10.1179/1743280412y.0000000002
摘要
Marine organisms are constituted by materials with a vast range of properties and characteristics that may justify their potential application within the biomedical field. Moreover, assuring the sustainable exploitation of natural marine resources, the valorisation of residues from marine origin, like those obtained from food processing, constitutes a highly interesting platform for
\ndevelopment of novel biomaterials, with both economic and environmental benefits. In this perspective, an increasing number of different types of compounds are being isolated from aquatic organisms and transformed into profitable products for health applications, including controlled drug delivery and tissue engineering devices. This report reviews the work that is being developed on the isolation and characterisation of some polysaccharides, proteins, glycosaminoglycans and ceramics from marine raw materials. Emphasis is given to agar, alginates, carrageenans, chitin and chitosan, among other polysaccharides, collagen, glycosaminoglycans such as chondroitin sulphate, heparin and hyaluronic acid, calcium phosphorous compounds and biosilica. Finally, this report ends by reviewing the application of the previously mentioned materials on specific biomedical applications, in particular their participation on the development of controlled drug delivery systems and tissue engineering scaffolds.
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