Downmodulation of key inflammatory cell markers with a topical Janus kinase 1/2 inhibitor
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Naresh Punwani,Timothy C. Burn,Peggy Scherle,Roberto Ventura-Flores,Jack Shi,Paul Collier,Denise Hertel,Patrick J. Haley,Young Lo,Paul Waeltz,James D. Rodgers,Stacey Shepard,Kris Vaddi,Swamy Yeleswaram,Richard Levy,William V. Williams,Alice B. Gottlieb
Topical INCB018424 dosed for 28 days QD or BID is pharmacologically active in patients with active psoriasis and modulates proinflammatory cytokines in the pathogenesis of psoriatic lesions.
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