卵巢早衰
衰老
更年期
雌激素
体细胞
卵巢早衰
生物
早衰
人口
表型
医学
生物信息学
生理学
内分泌学
内科学
遗传学
环境卫生
基因
作者
Lubna Pal,Nanette Santoro
标识
DOI:10.1016/s1568-1637(02)00009-0
摘要
Premature ovarian failure (POF) is a unique example of isolated organ senescence, with a population prevalence of approximately 1%. Though the phenotypic expression of POF is similar to that of age-appropriate natural menopause, the underlying pathophysiological mechanisms are diverse and not entirely clear. The impact of POF on the patient is profound, with myriad ramifications, ranging from psychological devastation to multi-system implications of estrogen deprivation and its sequelae. The hastening of degenerative changes noted in these patients however, are not entirely ameliorated with estrogen replacement and POF may indeed represent an acceleration of the aging process.
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