Pyridonecarboxylic acids as antibacterial agents. XII. Synthesis and antibacterial activity of enoxacin analogues with a variant at position 1.

Synthesis and antibacterial activity of enoxacin analogues [1-substituted 6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl)-1, 8-naphthyridine-3-carboxylic acids] were studied. Alkyl, hydroxyalkyl, chloroalkyl, aralkyl and alkenyl groups were selected as substituents at position 1. Among the compounds prepared in this work, the 1-(2-chloroethyl) analogue is the most active.