The premature ovarian failure had more than a cause of the syndrome,most of the patients with an unknown etiology.There are many factors that can cause women premature ovarian failure,the main factors including genetic,immune,metabolic,iatrogenic,infection factors and psychological factors,etc.The premature ovarian failure has a serious effect on women's health,it can lead to amenorrhea,infertility patients,the urinary tract disease,cardiovascular disease,etc.Therefore,the research of related factors and the health of women with premature ovarian failure are becoming more and more attention.In this paper we sum up the impact on related factors and the health of women with premature ovarian failure.