Apoptosis-regulating gene Bcl-2 and Bag-1 expression in cervical carcinogenesis

Objective:To investigate the expression of Bcl-2,Bag-1 in the pathogenesis and progression of cervical cancer and their relationship.Methods:S-P immunohistochemical analysis was performed in 36 cervical carcinoma and 64 cases of CIN.Results:Overexpression of Bcl-2 and Bag-1 protein in CIN and cervical cancer was remarkably higher than that in the control(P0.01),whereas the difference between CIN and cervical cancer was not significant(P0.05).Bcl-2 protein expression was positive correlation with Bag-1 protein expression in cervical carcinoma.Conclusion:Bag-1 and Bcl-2 overexpression might play an important role in the pathogenesis and development of cervical cancer.The overexpressions of Bcl-2 and Bag-1 are the early event of cervical carcinogenesis which are associated with the development of cervical carcinoma.Bcl-2 and Bag-1 protein in the development of cervical carcinoma enhance each other.