The dried,no moldy and representative samples from residue of Pleurotus ferulae were chosen and crushed 40 mesh,then cut short into 200 g by using quartation.The nutrient components from residue of Pleurotus ferulae were measured separately by using national standards act.The results showed that the crude fibre from residue of Pleurotus ferulae was hydrolyzed in great degree and the content of its crude protein and carbohydrate was higher than that of main material.And it was rich in mineral element,vitamin and amino acid.Then the allelopathic effects of aquatic extraction substance from residue of Pleurotus ferulae on mycelium growth of Coprinus comatus,Lentinula edodes,Pleurotus eryngii and Flammulinave lutipes were conducted by using plate method.We found that the allelopathic effects of its extraction solution on mycelium growth of four edible fungi was notable.The mycelium growth of Lentinula edodes and Flammulinave lutipes increased markedly in PDA culture medium,which contained separately 30% and 50% aquatic extraction substance.The mycelium growth of Coprinus comatus was inhibited in evidence in PDA culture medium,which contained 50% extraction solution.And the mycelium growth of Pleurotus eryngii was almost inhibited in PDA culture medium,except contained 10% extraction solution.