Potential function targets of antidepressants which is neurotrophic factors and neurogenesis

Antidepressants has been applied for the treatment of depression for decades.Until now,however,the mechanisms underlying the therapeutic efficacy of antidepressants remain unknown.A growing body of research supports that antidepressants can increase the neurotrophic factor expression and neurogenesis in the hippocampus.Furthermore,antidepressants block or reverse stress-induced downregulation of neurotrophic factor expression in brain and neurogenesis in the hippocampus.At the same time,the therapeutic efficacy of antidepressants require neurotrophic factor and neurogenesis.Thus,the regulation of neurotrophic factor expression in the brain and neurogenesis in the hippocampus may provide additional targets for the development of novel,more efficacious antidepressant drugs.