Objective To understand the distribution and endemic tendency of clonorchiasis in Shandong Province and provide scientific evidences for controlling the disease Methods The method of kato-katz was used to examine the clonorchis sinensis ova in stool. The data concerning the control of clonorchiasis sinensis were collected and analyzed. Results There were 107 counties prevalent with clonorchiasis sinensis in Shandong Province before 1987 year. The infection rate of population was 1.51%. The infected counties were 77% and totally 1130 000 people were infected. After a control of 40 years the infection rate of clonochis sinensis in population reduced from 1.51% to 0.06%, a drop of 96%.The numberof oountries prevalent with the disease reduced from 107 to 51; the numbers of counties at risk reduced from 77% to 36.7%, a drop of 52.3%. The number of infections reduced from 1 130 000 to 50000 .While the number of people with light infection increased from 63.7% to 88.2%. Conclusion The prevalent areas of clonorchiasis sinensis is reducing gradually, and the number of people at risk is on the decreasing year by year. The average infection of the clonorchiasis sinensis is at the lowest level and 88.2% of the infections were light infection. The goal of controlling the transmission of clonorchiasis sinensis has been achieved basically in Shandong Province.