Effect of Qianliean on Basic Fibroblast Growth Factorlevelsin in Rats Model of Benign Prostatic Hyperplasia

Objective:To investigate the effect of Qianliean on the treatment of benign prostatic hyperplasia and the related mechanism.Method:Rat model of benign prostatic hyperplasia was established by castration followed by injection of testosterone.The rats were randomly divided into 5 groups:the normal group,the model group,the Qianliean high-dose group,the Qianliean low-dose group,Longbishu group.The rats were treated accordingly and sacrificed after 30 d.The prostates were sampled and weighed,and the prostate index was calculated.Light microscopic and immunohistochemical specimens were prepared and investigated.Result:Prostatic weight,prostatic index and basic fibroblast growth factorlevelsin(bFGF) expression levels in three treatment groups were significantly lower than that of the model group,in particular for the Qianliean of high-dose group.Model group showed marked pathological changes in prostate tissue,Qianliean low-dose group showed alleviated pathological changes in prostate tissue compared with the model group,high-dose group and Longbishu group rats prostate tissue showed obvious improvement in pathological changes.Conclusion: Qianliean can decrease prostate wet weight in rat and alleviate pathological damage in prostate.The mechanism may be related to the inhibition of prostate tissue bFGF release.