Relationship between plasma brain natriuretic peptide level and left ventricular remodeling and prognostic value in chronic heart failure patients

Objective To investigate the relationship between brain natriuretic peptide(BNP) level and left ventricular remodeling and prognostic value in chronic heart failure(CHF) patients.Methods The plasma BNP concentrations of 126 CHF patients were measured quickly by luminoimmunoassay.The main adverse cardiac events(MACE,including cardiavarscular death,recurrent heart failure/readmission for HF worsening) were analyzed at inhospital and 30 days and 6 months.Results With the higher BNP values in CHF group gradually,LVMI and LVIDdI increasing,and LVEF decreasing distinctly with the higher incidence of MACE.After adjustment for clinical prognostic factors,such as ages,LVMI,LVIDdI,and LVEF in CHF groups,BNP level remained significantly independent predictor for MACE at 30 days(r=0.769,P0.01) and 6 months(r=0.831,P0.01) by multivariate logistic regression analysis.The Area under receiver operating characteristic(ROC) curve was 0.851(95%CI 0.778-0.924,P0.01) for incidence of MACE at 6 months.Conclusion Plasma BNP level is related with left ventricular remodeling,and it is a significantly independent predictor for MACE in patients with CHF.