Objective:To investigate the clinical significance of squamous cell carcinoma antigen(SCC-Ag) as a tumor marker in the diagnosis and clinical monitor of cervical squamous cell carcinoma,and the relationship between serum SCC-Ag level and clinical stage of cervical cancer.Methods:Squamous cell carcinoma antigen(SCC-Ag) was measured in serum from 107 cervical squamous cell carcinoma patients and control group.Results:Serum SCC-Ag level in patients with squamous cell carcinoma of cervix increased with elevation of clinical stage(P0.01).Conclusion:SCC-Ag is a specific tumor marker of the squamous cell carcinoma of cervix.SCC-Ag can be used as a marker for adjuvant diagnosis of cervical cancer and to estimate the surgical efficacy and as a clinical monitor.