医学
青少年类风湿关节炎
血沉
血管内皮生长因子
内科学
关节炎
发病机制
免疫学
类风湿因子
类风湿性关节炎
胃肠病学
全身性疾病
免疫病理学
血管内皮生长因子受体
作者
Nobuaki Maeno,Syuji Takei,Hiroyuki Imanaka,Ichiro Takasaki,Isao Kitajima,I Maruyama,Katsuhiko Matsuo,Koichiro Miyata
出处
期刊:PubMed
日期:1999-10-01
卷期号:26 (10): 2244-8
被引量:19
摘要
To investigate the relevance of vascular endothelial growth factor (VEGF) in the pathogenesis of juvenile rheumatoid arthritis (JRA).Serum VEGF levels in 58 patients with JRA (systemic in 17, polyarticular in 29, pauciarticular in 12) were measured by ELISA and compared with those of 21 patients with infectious diseases and 50 healthy children. Correlations of VEGF levels with number of joints with active arthritis, erythrocyte sedimentation rate (ESR), and hyaluronic acid (HA) were examined.Serum levels of VEGF in patients with JRA were significantly higher than in healthy controls. Patients with systemic and polyarticular JRA showed statistically higher levels of VEGF than those with infectious diseases. VEGF levels correlated statistically with C-reactive protein (CRP) in patients with both infectious diseases and polyarticular JRA, but the regression slope (VEGF/CRP) was much steeper in polyarticular JRA than in infectious diseases. Serum VEGF levels correlated with disease activity variables such as the number of joints with active arthritis, ESR, and serum HA levels in polyarticular JRA.The correlation of serum VEGF levels and disease activity in polyarticular JRA suggests that VEGF may take an active part in joint inflammation.
科研通智能强力驱动
Strongly Powered by AbleSci AI