粒体自噬
医学
烧伤
伤口愈合
败血症
线粒体
炎症
自噬
平衡
生物信息学
重症监护医学
细胞生物学
免疫学
生物
外科
内科学
细胞凋亡
生物化学
作者
Harshini Sheeja Prabhakaran,Dongxue Hu,He Wang,Gaoxing Luo,Yih‐Cherng Liou
出处
期刊:Burns & Trauma
[Oxford University Press]
日期:2023-01-01
卷期号:11
被引量:2
标识
DOI:10.1093/burnst/tkad029
摘要
Abstract Burn injuries are a significant cause of death worldwide, leading to systemic inflammation, multiple organ failure and sepsis. The progression of burn injury is explicitly correlated with mitochondrial homeostasis, which is disrupted by the hyperinflammation induced by burn injury, leading to mitochondrial dysfunction and cell death. Mitophagy plays a crucial role in maintaining cellular homeostasis by selectively removing damaged mitochondria. A growing body of evidence from various disease models suggest that pharmacological interventions targeting mitophagy could be a promising therapeutic strategy. Recent studies have shown that mitophagy plays a crucial role in wound healing and burn injury. Furthermore, chemicals targeting mitophagy have also been shown to improve wound recovery, highlighting the potential for novel therapeutic strategies based on an in-depth exploration of the molecular mechanisms regulating mitophagy and its association with skin wound healing.
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