医学
荟萃分析
虚弱指数
观察研究
脊髓损伤
梅德林
优势比
系统回顾
人口
内科学
老年学
精神科
环境卫生
政治学
法学
脊髓
作者
Faramarz Roohollahi,Farzin Farahbakhsh,Samuel Berchi Kankam,Mohammad Hossein Mohammadi,Aynaz Mohammadi,Rojin Korkorian,Sepehr Hobabi,Azin Moarrefdezfouli,Shervin Molavi,Benjamin Davies,Carl Moritz Zipser,Ilya Laufer,James S. Harrop,Paul M. Arnold,Allan Martín,Vafa Rahimi-Movaghar
标识
DOI:10.1089/neu.2023.0008
摘要
Although many frailty tools have been used to predict traumatic spinal injury (TSI) outcomes, identifying predictors of outcomes after TSI in the aged population is difficult. Frailty, age, and TSI association are interesting topics of discussion in geriatric literature. However, the association between these variables are yet to be clearly elucidated. We conducted a systematic review to investigate the association between frailty and TSI outcomes. The authors searched Medline, EMBASE, Scopus, and Web of Science for relevant studies. Studies with observational designs that assessed baseline frailty status in individuals suffering from TSI published from inception until 26th March 2023 were included. Length of hospital stay (LoS), adverse events (AEs), and mortality were the outcomes of interest. Of the 2425 citations, 16 studies involving 37,640 participants were included. The modified frailty index (mFI) was the most common tool used to assess frailty. Meta-analysis was employed only in studies that used mFI for measuring frailty. Frailty was significantly associated with increased in-hospital or 30-day mortality (pooled odds ratio [OR]: 1.93 [1.19; 3.11]), non-routine discharge (pooled OR: 2.44 [1.34; 4.44]), and AEs or complications (pooled OR: 2.00 [1.14; 3.50]). However, no significant relationship was found between frailty and LoS (pooled OR: 3.02 [0.86; 10.60]). Heterogeneity was observed across multiple factors, including age, injury level, frailty assessment tool, and spinal cord injury characteristics. In conclusion, although there is limited data concerning using frailty scales to predict short-term outcomes after TSI, the results showed that frailty status may be a predictor of in-hospital mortality, AEs, and unfavorable discharge destination.
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