A pathway linking atopic dermatitis to skin microbes

Interactions between microbiota and host skin have an important impact on cutaneous immunity and inflammation. In this issue of Cell Host & Microbe, Cha et al. report that skin commensal bacteria-mediated priming of group 2 innate lymphoid cells in early life predisposes the mice to atopic dermatitis-like inflammation in adulthood. Interactions between microbiota and host skin have an important impact on cutaneous immunity and inflammation. In this issue of Cell Host & Microbe, Cha et al. report that skin commensal bacteria-mediated priming of group 2 innate lymphoid cells in early life predisposes the mice to atopic dermatitis-like inflammation in adulthood. Skin microbe-dependent TSLP-ILC2 priming axis in early life is co-opted in allergic inflammationCha et al.Cell Host & MicrobeJanuary 9, 2024In BriefCha and colleagues report that early postnatal colonization with skin commensal microbiota, particularly IAld-producing Staphylococcus species, induces ILC2 priming mediated by keratinocyte-derived TSLP. This early ILC2 priming during the postnatal period, actively promotes allergic skin inflammation in adulthood. Full-Text PDF