肺纤维化
肺表面活性物质
纤维化
肺
背景(考古学)
片状颗粒
特发性肺纤维化
表面张力
顺从(心理学)
医学
材料科学
化学
病理
内科学
生物
生物化学
古生物学
物理
社会心理学
量子力学
心理学
作者
Xin Li,Jianzhong Zhang,Mingyue Wang,Chao Du,Wenjing Zhang,Yingying Jiang,Wanjun Zhang,Xinyu Jiang,Dunqiang Ren,Hongmei Wang,Xinru Zhang,Yuxin Zheng,Jinglong Tang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-12-15
标识
DOI:10.1021/acsnano.3c05956
摘要
Multiwalled carbon nanotubes (MWCNTs) have been widely used in many disciplines and raised great concerns about their negative health impacts, especially environmental and occupational exposure. MWCNTs have been reported to induce fibrotic responses; however, the underlying mechanisms remain largely veiled. Here, we reported that MWCNTs inhalation induced lung fibrosis together with decreased lung compliance, increased elastance in the mice model, and elevated surface tension in vitro. Specifically, MWCNTs increased surface tension by impairing the function of the pulmonary surfactant. Mechanistically, MWCNTs induced lamellar body (LB) dysfunction through autophagy dysfunction, which then leads to surface tension elevated by pulmonary surfactant dysfunction in the context of lung fibrosis. This is a study to investigate the molecular mechanism of MWCNTs-induced lung fibrosis and focus on surface tension. A direct mechanistic link among impaired LBs, surface tension, and fibrosis has been established. This finding elucidates the detailed molecular mechanisms of lung fibrosis induced by MWCNTs. It also highlights that pulmonary surfactants are expected to be potential therapeutic targets for the prevention and treatment of lung fibrosis induced by MWCNTs.
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