N,N-Dimethylamino Phenyl Curcumin Drug Loaded Polyethylene Glycol-Chitosan Incorporated Zinc Oxide Nanoparticles for Anti-Arthritic Activity

Arthritis is a chronic autoimmune inflammatory disease in which healthy cells and tissues in the body are attacked by the body's own immune system.Inflammation leads to over-activation, differentiation and proliferation of lymphocytes.The aim of this study is to do in-vitro studies with Chitosan-Polyethylene glycol polymer-coated ZnO nanoparticles which carry NN-Dimethylaminocurcumin (NNDMA Cur) synthetic form of curcumin as the drug in the treatment of arthritis.The NNDMA Cur loaded Zinc Oxide nanoparticles were prepared using a hydrothermal method and characterized with certain techniques such as Powder X-ray diffraction, Fourier transform infrared, UV-Visible spectroscopy, Transmission electron microscope, Nuclear magnetic resonance, Electrospray ionization-Mass spectrum and in-vitro drug releasing studies.The obtained results proved that drug NNDMA Cur was continuously released, especially at pH 5.4, which is optimal for drug absorption by humans.The percentage of inhibition for the produced nanocomposite NNDMA Cur-PEG-CS-ZnO is determined to be effective for antiarthritic activity.