Reimagining optimization of clinical trials efficiency through use of statistical innovation, technology and non-standard data sources

With the ever-growing cost of conducting traditional clinical trials and evolving regulatory paradigms, the need to deliver new medicines with speed and efficiency has become increasingly urgent. There are complex and innovative design approaches, emerging technologies, and abundant data sources that can be leveraged to address these challenges. However, their potential is not fully realized due to operational constraints and regulatory hurdles. We review the vast array of tools and technologies that are available, discuss their capabilities and limitations, and propose strategies for maximizing the efficiency of clinical trials through effective deployment of existing and new approaches.