卵菌
辣椒疫霉
熊果酸
化学
立体化学
食品科学
生物化学
胡椒粉
色谱法
基因
作者
Lina Zhu,Yuee Tian,Tiewei Wang,Xiaobo Huang,Lin Zhou,Shengming Liu,Genqiang Chen,Zhiping Che
标识
DOI:10.1080/14786419.2023.2207135
摘要
Using ursolic acid (UA) as the lead compound, thirteen UA ester derivatives (3 and 7a-l) were synthesized by modifying their C-3 and C-28 positions, respectively, and their structures were well characterized by 1H NMR, 13C NMR, HRMS and melting points. Furthermore, we evaluated the anti-oomycete and anti-fungal activities of these compounds against Phytophthora capsici and Fusarium graminearum in vitro. The results showed that compound 7h exhibited prominent anti-oomycete and anti-fungal activities, and the median effective concentration (EC50) values of 7h against P. capsici and F. graminearum were 70.49 and 113.21 mg/L, respectively. This study suggested that the anti-oomycete and anti-fungal activities of esters synthesized by introducing acyloxy group at C-3 position of UA was more conspicuous than that of esters synthesized by introducing benzyloxy group at C-28 position. This result will pave the way for further modification of UA to develop potential new fungicides.
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