弹性蛋白
血管平滑肌
α-硫辛酸
主动脉瘤
硫辛酸
动脉瘤
主动脉
主动脉夹层
医学
解剖(医学)
血管疾病
内科学
心脏病学
药理学
生物
病理
平滑肌
外科
氧化应激
生物化学
抗氧化剂
作者
Rongle Liu,Sui-Shane Huang,Hongtao Shi,Shufu Chang,Junbo Ge
出处
期刊:Life Sciences
[Elsevier]
日期:2022-12-01
卷期号:311: 121159-121159
标识
DOI:10.1016/j.lfs.2022.121159
摘要
Alpha-Lipoic acid (ALA) plays a protective role in a variety of vascular diseases, however, its effect on aortic aneurysm and dissection (AAD) has not been reported. In this study, we found that Alpha-Lipoic Acid treatment significantly improved the AAD and AAA development, which was demonstrated by ameliorated aneurysmal dilation, decreased aortic dissection and aneurysm incidence, improved aortic morphology and inhibited elastin degradation. ALA blunted extra-cellular matrix degradation, vascular smooth muscle cell (VSMC) loss and phenotype transformation. Moreover, the protective effect of ALA on VSMCs may be related to the amelioration of mitochondrial dysfunction. In conclusion, our study revealed that ALA exerts inhibitory effects against progression of AAD, thus suggesting that ALA may be a novel therapeutic molecule for AAD.
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