Abstract Artificial intelligence has become an essential tool across various fields of medicine, enabling new patterns of innovation such as precision medicine, neurosciences, genomics, and proteomics. This article aims to synthesize the main ethical challenges arising from the application of artificial intelligence in medicine, in order to promote responsible implementation of these digital technologies, always serving people and humanity. Additionally, it proposes a set of recommendations for developing trustworthy artificial intelligence in the medical context. Methodologically, an in-depth analysis was conducted of the main international ethical and legal instruments regulating artificial intelligence. It is concluded that effective ethical governance is essential to preserve human agency in the application of artificial intelligence systems and to ensure full transparency in research and development processes.