Oestrogen-related receptor γ in sepsis-induced cardiomyopathy: role of cardiomyocyte subtype conversion

This study not only identifies cardiomyocyte subtype conversions as a key pathophysiological basis for SICM-induced cardiac dysfunction but also establishes ERRγ as the central regulatory mechanism governing these conversions. Activating ERRγ has the potential to ameliorate cardiac dysfunction in SICM. This work provides new insights into the pathophysiology of SICM, offering novel therapeutic strategies for its prevention and treatment.