化学
全合成
天然产物
羟醛反应
环闭合复分解
立体化学
组合化学
盐变质反应
复分解
有机化学
催化作用
聚合
聚合物
作者
Moinul Haque Sahana,Debasish Paul,Himangshu Sharma,Rajib Kumar Goswami
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-10-19
卷期号:25 (43): 7827-7831
标识
DOI:10.1021/acs.orglett.3c03066
摘要
A convergent route for the asymmetric total synthesis of antibacterial macrolide sorangiolide A has been developed for the first time. The key feature of this synthesis includes Krische iridium-catalyzed anti-diastereoselective carbonyl crotylation, Crimmins acetate aldol, Yamaguchi esterification, Julia-Kocienski olefination, Horner-Wadsworth-Emmons olefination, and ring-closing metathesis. The origin of the low intensity of the 13C{1H} NMR signals of the C1 and C2 centers of the natural product has been investigated, disclosing possible forms of existence for the natural product in the solution phase.
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