p38丝裂原活化蛋白激酶
肝细胞癌
细胞凋亡
氧化应激
MAPK/ERK通路
抑制器
癌症研究
化学
细胞生物学
信号转导
生物标志物
线粒体
活性氧
抑癌基因
癌症
下调和上调
肿瘤坏死因子α
生物
机制(生物学)
酶激活剂
战斗或逃跑反应
癌
医学
内源性凋亡
作者
Huihui Shi,Lei Chen,Juan Huang,Xuejing Lin,Lei Huang,Min Tang,Ke Lu,Wenchao Wang,Maoling Zhu
出处
期刊:Oncology Research
[Cognizant Communication Corporation]
日期:2025-10-09
卷期号:34 (1): 1-10
标识
DOI:10.32604/or.2025.068737
摘要
CSRNP1 is a novel prognostic biomarker and tumor suppressor in HCC. It exerts anti-tumor effects by inducing oxidative stress and activating the JNK/p38 MAPK pathway in a ROS-dependent manner. These findings suggest that CSRNP1 may serve as a potential therapeutic target in the management of HCC.
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