医学
体温过低
随机对照试验
病变
冲程(发动机)
临床试验
麻醉
外科
内科学
机械工程
工程类
作者
Michael A. De Georgia,Derk Krieger,Alex Abou-Chebl,Thomas Devlin,M. Jauss,Stephen Davis,Walter J. Koroshetz,Guy Rordorf,Steve Warach
出处
期刊:Neurology
[Ovid Technologies (Wolters Kluwer)]
日期:2004-07-26
卷期号:63 (2): 312-317
被引量:342
标识
DOI:10.1212/01.wnl.0000129840.66938.75
摘要
Objective: To report results of a randomized pilot clinical feasibility trial of endovascular cooling in patients with ischemic stroke. Methods: Forty patients with ischemic stroke presenting within 12 hours of symptom onset were enrolled in the study. An endovascular cooling device was inserted into the inferior vena cava of those randomized to hypothermia. A core body temperature of 33 °C was targeted for 24 hours. All patients underwent clinical assessment and MRI initially, at days 3 to 5 and days 30 to 37. Results: Eighteen patients were randomized to hypothermia and 22 to receive standard medical management. Thirteen patients reached target temperature in a mean of 77 ± 44 minutes. Most tolerated hypothermia well. Clinical outcomes were similar in both groups. Mean diffusion-weighted imaging (DWI) lesion growth in the hypothermia group (n = 12) was 90.0 ± 83.5% compared with 108.4 ± 142.4% in the control group (n = 11) (NS). Mean DWI lesion growth in patients who cooled well (n = 8) was 72.9 ± 95.2% (NS). Conclusions: Induced moderate hypothermia is feasible using an endovascular cooling device in most patients with acute ischemic stroke. Further studies are needed to determine if hypothermia improves outcome.
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