Ultralow-Dose Micronized 17β-Estradiol and Bone Density and Bone Metabolism in Older Women

In older women, a dosage of 0.25 mg/d of 17beta-estradiol increased bone density of the hip, spine, and total body, and reduced bone turnover, with minimal adverse effects. Future studies evaluating the effect of low-dose estrogen on fractures are indicated.