米兰标准
医学
肝细胞癌
肝移植
内科学
比例危险模型
胃肠病学
危险系数
对数秩检验
阶段(地层学)
癌
外科
生存分析
总体生存率
移植
置信区间
古生物学
生物
作者
Heng Fan,Teng-Wei Chen,Chung-Bao Hsieh,Hsiang-Chun Jan,Sheng-Chuan His,De-Chuan Chan,Chin-Chen Chu,Jyh‐Cherng Yu
标识
DOI:10.1016/j.amjsurg.2009.07.049
摘要
The decision to perform liver transplantation (LT) or liver resection (LR) for patients with hepatocellular carcinoma (HCC) who are beyond the Milan criteria remains controversial.We retrospectively analyzed outcome data for 179 patients with HCC beyond the Milan criteria who were treated with LR (n = 135) or LT (n = 44). Univariate and multivariate Cox proportional hazard models were established. Kaplan-Meier survival curves were generated, and a log-rank test was performed to compare group survival status.Patients who underwent LR group were significantly older, had a lower TNM stage, and were more likely to have unilateral disease and noncirrhotic liver. Significantly more patients in the LR group had recurrence (53.3% vs 29.5%) or died (61.5% vs 43.2%) than patients in the LT group. Recurrence-free survival rates were 11.9% for the LR group and 61.5% for the LT group. The median overall survival duration showed no statistically difference between the LR group (28.0 months) and the LT group (50.0 months).LT may be the better choice for patients with HCC beyond the Milan criteria.
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