脑炎
自身抗体
抗体
免疫学
癫痫
自身免疫性脑炎
医学
免疫疗法
病毒学
生物
病毒
免疫系统
精神科
作者
S.W. Rogers,P. Ian Andrews,Gahring Lc,Teri D. Whisenand,Keith A. Cauley,B J Crain,TE Hughes,Sabine Heinemann,J. O. McNamara
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1994-07-29
卷期号:265 (5172): 648-651
被引量:634
标识
DOI:10.1126/science.8036512
摘要
Rasmussen's encephalitis is a progressive childhood disease of unknown cause characterized by severe epilepsy, hemiplegia, dementia, and inflammation of the brain. During efforts to raise antibodies to recombinant glutamate receptors (GluRs), behaviors typical of seizures and histopathologic features mimicking Rasmussen's encephalitis were found in two rabbits immunized with GluR3 protein. A correlation was found between the presence of Rasmussen's encephalitis and serum antibodies to GluR3 detected by protein immunoblot analysis and by immunoreactivity to transfected cells expressing GluR3. Repeated plasma exchanges in one seriously ill child transiently reduced serum titers of GluR3 antibodies, decreased seizure frequency, and improved neurologic function. Thus, GluR3 is an autoantigen in Rasmussen's encephalitis, and an autoimmune process may underlie this disease.
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