微流控
材料科学
纺纱
纳米技术
制作
纳米尺度
复合材料
医学
病理
替代医学
作者
Edward Kang,Gi Seok Jeong,Yoon Young Choi,Kwang Ho Lee,Ali Khademhosseini,Sang Hoon Lee
出处
期刊:Nature Materials
[Springer Nature]
日期:2011-09-04
卷期号:10 (11): 877-883
被引量:399
摘要
Heterotypic functional materials with compositional and topographical properties that vary spatiotemporally on the micro- or nanoscale are common in nature. However, fabricating such complex materials in the laboratory remains challenging. Here we describe a method to continuously create microfibres with tunable morphological, structural and chemical features using a microfluidic system consisting of a digital, programmable flow control that mimics the silk-spinning process of spiders. With this method we fabricated hydrogel microfibres coded with varying chemical composition and topography along the fibre, including gas micro-bubbles as well as nanoporous spindle-knots and joints that enabled directional water collection. We also explored the potential use of the coded microfibres for tissue engineering applications by creating multifunctional microfibres with a spatially controlled co-culture of encapsulated cells.
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